Development of experimental setup to create novel mental disorder model rats using small mobile robot

Abstract

The number of patients with mental disorders is increasing in advanced countries. Many researchers are working to develop mental disorder model animals that contribute to development of new psychotropic drugs. However, we have some doubts about conventional mental disorder models. Therefore, the purpose of this study is to develop an experimental setup to create novel mental disorder model animals. We then developed a small mobile robot and a control system for the robot. Using them, we performed an experiment to develop a mental disorder model rat. In the experiment, we succeeded in developing a new depression model rat and also high activity model rat. These disorder models must be useful in the screening of new psychotropic drugs. In addition, the methodology we developed in this research will contribute to clarifying mechanisms of mental disorders.