Bromodomain

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Laurent Hoffer, Yu. V. Voitovich, Brigitt Raux, Kendall Carrasco, Christophe Müller, Alexey Yu. Fedorov, Carine Derviaux, Agnès Amouric, S. Betzi, Dragos Horvath, Alexandre Varnek, Yves Collette, Sébastien Combes, Philippe Roche, Xavier Morelli

引用数: 72 • 2018

Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography

Harold Grosjean, Anthony Aimon, Storm Hassell‐Hart, Warren Thompson, L. Koekemoer, James M. Bennett, A.R. Bradley, C.A. Anderson, Conor Wild, W.J. Bradshaw, Edward A. Fitzgerald, T. Krojer, O. Fedorov, Philip C. Biggin, John Spencer, F. von Delft

引用数: 9 • 2025