Laurent Hoffer
Papers
1
Total Citations
72
H-Index
1
About
Dr. Laurent Hoffer is a leading figure in computational and medicinal chemistry, whose work has fundamentally advanced the field of drug discovery. His primary research focuses on the critical transition from hit identification to lead optimization, a major bottleneck in pharmaceutical development. Dr. Hoffer’s most impactful contribution is the development of an integrated strategy for lead optimization based on fragment growing, known as the Diversity-Oriented-Target-Focused-Synthesis (DOTFS) approach. This time- and cost-efficient methodology, detailed in his highly cited 2018 paper (72 citations), automates the hit-to-lead (H2L) process by combining fragment-based screening with targeted synthesis, dramatically accelerating the journey from initial hits to viable drug candidates. By addressing a key hurdle in process automation, his work provides a powerful, practical framework for designing more potent and selective compounds. Dr. Hoffer’s research is essential reading for any scientist seeking to bridge the gap between computational design and experimental synthesis in modern drug discovery.
Research Focus
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Top Papers
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