Is There a Future for DNA-Based Molecular Devices in Diabetes Management?

摘要

We provide a thought experiment in advanced molecular engineering leading to the construction of a molecular robot acting as a DNA-based closed-loop device for the management of diabetes mellitus. The key components of this robot are nucleic acid enzymes regulated allosterically by glucose. In the presence of glucose above a threshold level the robot moves, releasing insulin from a lawn covered with insulin, but stops in its tracks whenever glucose decreases to a level below threshold; thus, the robot could provide an insulin release response to spikes in glucose concentration in real time.