Design and Implementation of Novel Multifunctional 3D Bioprinter

摘要

3D bioprinting is a rapidly emerging biomedical variant of 3D printing technology. A 3D bioprinter could be defined as a robotic device for layer-by-layer biofabrication of 3D human tissues and organs from living cells and hydrogels according to a digital model. Development of commercial 3D bioprinters certifiable for clinical use will enable bioprinting 3D human tissues and organs suitable for implantation. The commercial multifunctional clinical 3D bioprinter of extrusion type suitable for robotic biofabrication of 3D human tissues and organs and potentially certifiable for clinical use is presented. The principle constructive feature of a 3D bioprinter is a separation of a cell printing process from hydrogel spraying, which allows the use of photo-sensitive hydrogel with ultraviolet-induced polymerization without cell damage. Some of its multiple potential functionalities have been tested and illustrated. Development of a clinical 3D bioprinter is an important step toward practical implementation of a highly desirable organ printing technology.