Phenotypic screening

Two approaches to discovering and developing new drugs for Chagas disease

McKerrow Jh, PS Doyle, Engel Jc, LM Podust, Sheilah A. Robertson, Rafaela Salgado Ferreira, T Saxton, Michelle R. Arkin, ID Kerr, LS Brinen, CS Craik

Citations: 173 • 2009

Activity-Based DNA-Encoded Library Screening

Wesley G. Cochrane, Marie L. Malone, Vương Đặng Quốc, V. Cavett, Alexander L. Satz, Brian M. Paegel

Citations: 85 • 2019

High-Throughput Screening of Zebrafish Embryos Using Automated Heart Detection and Imaging

Waldemar Spomer, Alexander Pfriem, Rüdiger Alshut, Steffen Just, Christian Pylatiuk

Citations: 67 • 2012

Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay

N.C. Gassner, Craig M. Tamble, Jonathan Bock, Naomi Cotton, Kimberly N. White, Karen Tenney, Robert P. St.Onge, Michael Proctor, Guri Giaever, Corey Nislow, Ronald W. Davis, Phillip Crews, Theodore R. Holman, R. Scott Lokey

Citations: 57 • 2007

ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates

David T. White, Arife Unal Eroglu, Guohua Wang, Liyun Zhang, S. Sengupta, Ding Ding, Surendra K. Rajpurohit, Steven L. Walker, Hongkai Ji, Jiang Qian, Jeff S. Mumm

Citations: 50 • 2016

Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research

Dean G. Brown, Heike J. Wobst

Citations: 49 • 2019

The Powerful Combination of Phage Surface Display of cDNA Libraries and High Throughput Screening

Reto Crameri, Rimantas Kodzius

Citations: 43 • 2012

Advances in Antiwolbachial Drug Discovery for Treatment of Parasitic Filarial Worm Infections

Malina A. Bakowski, Case W. McNamara

Citations: 38 • 2019

Chemoproteomics-driven drug discovery: addressing high attrition rates

Steven E. Hall

Citations: 36 • 2006

Selective enrichment and high-throughput screening of phage surface-displayed cDNA libraries from complex allergenic systems.

Reto Crameri, Gerald Walter

Citations: 23 • 1999

A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity

Franz Gruber, Zoe C Johnston, Christopher L. R. Barratt, Paul D. Andrews

Citations: 22 • 2020

A Chemical Genetics Approach for Specific Differentiation of Stem Cells to Somatic Cells: A New Promising Therapeutical Approach

Agapios Sachinidis, Isaia Sotiriadou, Bianca Seelig, Albrecht Berkessel, Jürgen Hescheler

Citations: 19 • 2008

Selective Enrichment and High-throughput Screening of Phage Surface-displayed eDNA Libraries from Complex Allergenic Systems

Reto Crameri, Gerald Walter

Citations: 18 • 1999

Improving Consistency of Cell-Based Assays by Using Division-Arrested Cells

Natalie Fursov, Mei Cong, Mark Federici, Michael Platchek, Peter Haytko, Roland Tacke, Thomas J. Livelli, Zhong Zhong

Citations: 17 • 2005

Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of <em>Arabidopsis thaliana</em>

B Kirtley Amos, Victoria G. Pook, Seth DeBolt

Citations: 11 • 2018

Recent Advances in Cancer Drug Discovery Through the Use of Phenotypic Reporter Systems, Connectivity Mapping, and Pooled CRISPR Screening

Natasha Salame, Katharine Fooks, Nehmé El-Hachem, Jean‐Pierre Bikorimana, François Mercier, Moutih Rafei

Citations: 10 • 2022