Yoshikazu Sugimoto
Papers
1
Total Citations
40
H-Index
1
About
Yoshikazu Sugimoto is a cell biologist and chemical geneticist whose research centers on the molecular mechanisms of DNA repair and telomere maintenance, with a particular focus on tankyrase enzymes. His most-cited work, "A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor" (2010, 40 citations), introduced an innovative high-throughput screening platform that leverages yeast genetics to discover small-molecule inhibitors of human tankyrase. This seminal contribution not only identified flavone as a promising lead compound for targeting telomere-related pathways but also established a versatile methodology for probing protein–protein interactions in a cellular context. Sugimoto’s approach has had lasting impact, providing a foundation for subsequent studies in cancer biology and aging research. His work exemplifies the power of cross-species screening to uncover therapeutic candidates, and his findings continue to inform the development of tankyrase inhibitors as potential anticancer agents. Through this creative fusion of yeast genetics and chemical biology, Sugimoto has made a distinctive mark on the field of telomere biology and drug discovery.
Research Focus
Key Achievements
Top Papers
- 1A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor40 citations · 2010