Tamio Saito
Papers
1
Total Citations
40
H-Index
1
About
Tamio Saito is a biochemist and chemical biologist whose research centers on the discovery and mechanistic study of small-molecule inhibitors targeting key cellular signaling pathways, with a particular focus on tankyrase enzymes and their role in cancer and aging. His most cited work, "A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor" (2010, 40 citations), introduced an innovative, high-throughput screening platform using engineered yeast cells to identify natural product inhibitors of tankyrase, a poly(ADP-ribose) polymerase involved in telomere maintenance and Wnt signaling. This study not only uncovered flavone as a promising lead compound but also demonstrated the utility of yeast-based systems for drug discovery, offering a cost-effective alternative to traditional mammalian cell assays. Saito’s contributions have provided foundational tools for probing tankyrase biology and have opened avenues for developing targeted therapies in colorectal cancer and other Wnt-driven diseases. With his work cited in fields ranging from chemical biology to oncology, Saito is recognized for bridging basic enzyme biochemistry with translational drug development.
Research Focus
Key Achievements
Top Papers
- 1A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor40 citations · 2010