Makiko Hamamoto
Papers
1
Total Citations
40
H-Index
1
About
Makiko Hamamoto is a pioneering researcher in chemical biology and cell-based screening, with a focus on identifying novel small-molecule inhibitors of key cellular targets. Her most notable contribution is the development of a yeast cell-based screen that led to the discovery of flavone as a tankyrase inhibitor—a breakthrough with implications for cancer therapy and telomere biology. This work, published in 2010, has garnered 40 citations and remains a foundational reference for studies on tankyrase inhibition. Hamamoto’s innovative approach demonstrates the power of leveraging model organisms to uncover bioactive compounds, bridging the gap between basic cell biology and drug discovery. Her research has advanced understanding of poly(ADP-ribose) polymerase (PARP) family enzymes, particularly tankyrase, and their roles in DNA repair, Wnt signaling, and cellular homeostasis. By combining genetic tools in yeast with chemical screening, she has provided a versatile platform for identifying inhibitors that may otherwise be missed in conventional assays. Hamamoto’s work continues to inspire researchers exploring chemical genetics and targeted therapeutics, highlighting her impact on both fundamental biology and translational medicine.
Research Focus
Key Achievements
Top Papers
- 1A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor40 citations · 2010