Yen-Nien Hou
Papers
1
Total Citations
38
H-Index
1
About
Yen-Nien Hou is a leading figure in translational radiation biology, whose work bridges molecular damage detection and clinical application. His primary research focuses on DNA double-strand break (DSB) signaling, particularly the quantification of γ-H2AX—a critical biomarker for ionizing radiation exposure. Hou’s most impactful contribution is the development of an automated γ-H2AX immunocytochemistry assay, published in 2009, which has garnered 38 citations. This innovation transformed a labor-intensive, qualitative technique into a high-throughput, quantitative tool, enabling precise assessment of radiation-induced DSBs in human cells, including PC-3 and DU145 prostate cancer lines. By automating the detection of this histone modification, Hou’s work has broadened the assay’s application in radiobiology, from evaluating therapeutic radiation responses to screening radioprotective agents. His method remains a foundational reference for researchers studying DNA damage repair and radiation sensitivity. Hou’s achievements underscore his role in advancing personalized radiotherapy, where rapid, accurate DSB quantification can guide treatment planning. For students and researchers, his work exemplifies how method development can drive mechanistic discovery and clinical translation in cancer biology.
Research Focus
Key Achievements
Top Papers
- 1Development of an Automated γ-H2AX Immunocytochemistry Assay38 citations · 2009