Xiaowu Liang
Papers
2
Total Citations
457
H-Index
2
About
Xiaowu Liang has pioneered transformative approaches at the intersection of genomics, immunology, and molecular diagnostics. His most influential contribution is the development of high-throughput proteome microarrays, a breakthrough that enabled comprehensive profiling of the humoral immune response to infectious diseases. This work, published in 2005 with over 420 citations, solved a critical bottleneck by creating a PCR recombination cloning and expression platform that could rapidly produce entire pathogen proteomes. The technology has been instrumental in accelerating vaccine and diagnostic antigen discovery, allowing researchers to systematically identify immune targets across multiple pathogens. Liang also introduced the Transcriptionally Active Polymerase Chain Reaction (TAP) method, which generates PCR fragments that can be directly expressed in vitro and in vivo without traditional cloning steps—a technique that has streamlined gene expression studies. His contributions have had a lasting impact on infectious disease research, providing tools that bridge the gap between genomic sequence data and functional immunological analysis. Liang’s work exemplifies how innovative molecular biology platforms can drive translational discoveries in vaccinology and diagnostics.
Research Focus
Key Achievements
Top Papers
- 1
- 2Transcriptionally Active Polymerase Chain Reaction (TAP)36 citations · 2002