Xiaoting Fang

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About

Xiaoting Fang is a pioneering researcher in the field of synthetic biology and natural product engineering, with a primary focus on ribosomally synthesized and post-translationally modified peptides (RiPPs), particularly lanthipeptides. Her major contribution lies in the development of a groundbreaking method for the robotic construction and high-throughput screening of lanthipeptide variant libraries directly in *Escherichia coli*, as detailed in her highly cited 2022 paper (18 citations). This work enables the rapid generation and evaluation of thousands of lanthipeptide analogs, overcoming traditional bottlenecks in peptide engineering and accelerating the discovery of novel bioactive compounds with enhanced stability and therapeutic potential. By establishing a recombinant *E. coli* platform for producing mature lanthipeptides—characterized by their signature thioether cross-links (lanthionine and methyllanthionine)—Fang has provided a powerful tool for exploring sequence-function relationships and optimizing these natural products for drug development. Her innovative approach has significant implications for antibiotic discovery and peptide-based therapeutics, marking her as a rising leader in the RiPPs engineering community.