Vikram Narayan
Papers
1
Total Citations
22
H-Index
1
About
Vikram Narayan is a structural and molecular biologist whose research centers on the molecular mechanisms of protein quality control, with a particular focus on the E3 ubiquitin ligase CHIP (Carboxy-terminus of Hsc70-Interacting Protein). His most cited work, "Protein–Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of CHIP" (2015, 22 citations), provides critical insight into how CHIP, a tetratricopeptide repeat (TPR) domain protein, functions beyond its well-known role in linking molecular chaperones to the ubiquitin-proteasome system. Narayan demonstrated that CHIP possesses a docking-dependent mode of action, allowing it to directly ubiquitinate native substrates and thereby regulate their steady-state levels. This finding expanded the understanding of CHIP’s regulatory capacity in cellular proteostasis. His contributions are particularly significant for researchers studying protein misfolding diseases, ubiquitin signaling, and chaperone biology. With a focused body of work that has garnered attention in the structural and cell biology communities, Narayan continues to illuminate the nuanced interplay between protein interactions and ubiquitin ligase activity.
Research Focus
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Top Papers
- 1