Vanina Zaremberg
Papers
1
Total Citations
89
H-Index
1
About
Vanina Zaremberg is a leading cell biologist whose research bridges membrane lipid dynamics, lipid–protein interactions, and cellular stress responses. Her pioneering work on the mechanisms of anti-cancer lysophospholipids, particularly edelfosine, has reshaped our understanding of how these drugs selectively target tumor cells. Using the model organism *Saccharomyces cerevisiae*, Zaremberg identified sterol and sphingolipid pathways as critical modulators of edelfosine cytotoxicity, demonstrating that the drug disrupts lipid raft composition to trigger cell death. Her landmark 2005 study, which has garnered nearly 90 citations, established a foundational framework for linking membrane lipid architecture to drug selectivity. Beyond this, Zaremberg has made significant contributions to the study of lipid droplet biology, autophagy, and the cellular response to nutrient deprivation, often employing innovative genetic and biochemical approaches. Her work is highly cited and continues to influence fields ranging from cancer therapeutics to basic membrane biology. Zaremberg is also recognized for her dedication to mentoring the next generation of scientists, fostering interdisciplinary research that bridges yeast genetics and human disease.
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