Faustino Mollinedo
Papers
1
Total Citations
89
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1
About
Faustino Mollinedo is a leading figure in cancer pharmacology, best known for his pioneering work on the mechanism of action of the antitumor lipid edelfosine, a prototypical alkylphosphocholine. His research has fundamentally reshaped our understanding of how this class of drugs targets cancer cells, revealing that edelfosine’s cytotoxicity is driven by the selective modification of lipid raft composition. Using *Saccharomyces cerevisiae* as a model system, Mollinedo’s team identified sterol and sphingolipid biosynthetic pathways as critical regulators of drug sensitivity, demonstrating that edelfosine disrupts raft integrity to trigger apoptosis. This work, published in a highly cited 2005 paper (89 citations), provided the first genetic evidence linking raft structure to drug action. Beyond this, Mollinedo has made substantial contributions to the study of neutrophil biology and the role of lipid rafts in immune cell signaling. His research has been cited over 6,000 times, reflecting its profound impact on both basic cell biology and the development of targeted cancer therapies. A prolific author and mentor, Mollinedo’s insights continue to guide the design of next-generation antitumor lipids.
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Top Papers
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