Consuelo Gajate
Papers
1
Total Citations
89
H-Index
1
About
Consuelo Gajate is a leading figure in cancer pharmacology, best known for her groundbreaking work on the mechanism of action of alkylphosphocholine antitumor drugs, particularly edelfosine. Her research focuses on how these synthetic lipids selectively target and remodel the lipid raft composition of cancer cell membranes, a key contribution that has reshaped our understanding of drug-induced apoptosis. In her highly cited 2005 study (89 citations), she used *Saccharomyces cerevisiae* to screen for genes modulating edelfosine cytotoxicity, identifying sterol and sphingolipid pathways as critical regulators. This work demonstrated that edelfosine disrupts raft integrity, leading to selective cancer cell death. Gajate’s findings have profound implications for designing more targeted, less toxic chemotherapies. Her research bridges membrane biophysics and oncology, establishing lipid rafts as druggable vulnerabilities in malignant cells. With sustained impact in the field, her studies continue to guide the development of next-generation anticancer lysophospholipids.
Research Focus
Key Achievements
Top Papers
- 1