Tanner Nevill

Papers

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About

Tanner Nevill is a leading figure in the development of high-throughput ion channel screening technologies, with a career focused on bridging the gap between automated electrophysiology and practical drug discovery. His primary research areas include microfluidic patch clamping, ion channel pharmacology, and the automation of membrane current measurements. Nevill’s major contributions center on the design and validation of novel platforms that dramatically increase the speed and consistency of ion channel assays, which are critical for both identifying new therapeutic compounds and assessing cardiac safety liabilities. His landmark 2011 study on the IonFlux system, which has garnered 40 citations, demonstrated the system’s utility for evaluating human *Ether-à-go-go* Related Gene (hERG) channel physiology and pharmacology, a cornerstone of preclinical safety screening. Expanding on this, his 2012 work (29 citations) established how well-plate microfluidics could automate patch clamping under flow conditions, enabling reproducible, high-throughput data generation. Through these innovations, Nevill has directly addressed the pharmaceutical industry’s need for optimized throughput and predictive accuracy in ion channel drug development.