T. Kendall Harden
Papers
1
Total Citations
25
H-Index
1
About
T. Kendall Harden is a pioneering pharmacologist and cell biologist whose research has fundamentally advanced our understanding of G protein-coupled receptor (GPCR) signaling and phospholipase C (PLC) regulation. His work has been instrumental in elucidating how small GTPases—particularly Rac and Rho—differentially activate specific PLC isozymes, a critical mechanism linking extracellular signals to intracellular calcium dynamics and cell growth. In a landmark 2006 study, Harden developed an intact cell assay system to quantify the isozyme-specific activation of PLC-β2 by Rac GTPases and PLC-ɛ by Rho GTPases, providing the first direct evidence of this selective regulation. This work, which has garnered over 25 citations, exemplifies his broader contributions to mapping the complex signaling networks that control cellular responses. Harden’s research has had a lasting impact on fields ranging from cancer biology to neuropharmacology, and his methodological innovations continue to be widely adopted. His career is marked by a relentless pursuit of mechanistic clarity, making him a foundational figure in signal transduction research and an inspiration for students exploring the molecular basis of cellular communication.
Research Focus
Key Achievements
Top Papers
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