Grace R Nakayama
Torrey Pines Institute For Molecular Studies, Pfizer (United States)
Papers
3
Total Citations
37
H-Index
3
About
Grace R. Nakayama is a biochemist and assay development specialist whose work has made meaningful contributions to drug discovery and enzymology, particularly in the design of high-throughput screening tools for therapeutic targets. Her research has centered on developing innovative biochemical assays to detect and measure enzyme activity, with a focus on protein kinases and viral enzymes implicated in disease. Nakayama's most influential contribution, a scintillating microplate assay for assessing protein kinase activity (1998, 17 citations), provided researchers with a practical and sensitive platform for evaluating kinase function — enzymes critical to cancer biology and signal transduction. Building on this foundation, she later developed a fluorescence polarization assay targeting the ribonuclease H activity of HIV-1 reverse transcriptase (2006, 15 citations), offering the scientific community a valuable tool for identifying potential anti-HIV therapeutics. Her immunoassay for receptor tyrosine kinase autophosphorylation (1999) further demonstrated her versatility in tackling diverse molecular targets. Though her citation counts are modest, Nakayama's methodological innovations represent essential infrastructure for drug screening pipelines, reflecting a career dedicated to enabling scientific discovery through rigorous, practical biochemical tools.
Research Focus
Key Achievements
Top Papers
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