David Bourdon
Papers
1
Total Citations
25
H-Index
1
About
David Bourdon’s research centers on the intricate signaling networks of small GTPases and phospholipase C (PLC) enzymes, with a focus on how these molecular switches orchestrate cellular responses. His most-cited work, a 2006 study, provided a critical methodological advance by developing an intact cell assay system to quantify isozyme-specific activation of PLC-β2 by Rac GTPases and PLC-ɛ by Rho GTPases. This contribution clarified the selective coupling between GTPase families and PLC isoforms, offering a more physiologically relevant framework for understanding signal transduction in processes like cell migration and growth. Though his citation count (25 for this key paper) reflects a focused, specialized impact, Bourdon’s work has been instrumental for researchers dissecting the specificity of G protein–effector interactions. His findings have implications for cancer biology and inflammatory diseases, where aberrant GTPase-PLC signaling is implicated. Bourdon’s dedication to precise, quantitative assays underscores his role as a meticulous experimentalist, advancing our grasp of how cells decode complex environmental cues through discrete molecular partnerships.
Research Focus
Key Achievements
Top Papers
- 1