Sylvain Engilberge
Centre National de la Recherche Scientifique, Institut de Biologie Structurale
Papers
2
Total Citations
15
H-Index
2
About
Sylvain Engilberge is a structural biologist whose research focuses on advancing protein crystallization through innovative chemical additives. His key contributions lie in the use of lanthanide-based complexes—specifically [Eu(DPA)₃]³⁻ and Tb-Xo4—as powerful auxiliaries for biocrystallography. In his most-cited work (2021, 12 citations), Engilberge systematically analyzed how divalent cations in commercial crystallization kits influence the efficiency of these lanthanide additives. This study revealed that the tris(dipicolinate) complexes can dramatically improve crystal quality and phasing, offering a robust tool for solving challenging protein structures. His follow-up work (3 citations) further refined these insights, demonstrating how subtle changes in crystallization conditions can optimize additive performance. By bridging coordination chemistry and structural biology, Engilberge has provided the community with practical, high-impact methods for overcoming crystallization bottlenecks. His research is especially valuable for researchers tackling membrane proteins or large complexes, where traditional crystallization often fails. With a growing citation record and a clear focus on methodological innovation, Engilberge is establishing himself as a key figure in the development of next-generation crystallization additives, making protein structure determination more accessible and reliable.
Research Focus
Key Achievements
Top Papers
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