Papers
2
Total Citations
15
H-Index
2
About
Seigo Shima is a leading structural biologist whose research centers on protein crystallography and the innovative use of lanthanide-based additives to solve challenging macromolecular structures. His major contributions lie in systematically understanding how divalent cations and lanthanide complexes—such as [Eu(DPA)₃]³⁻ and Tb-Xo4—influence the protein crystallization process. By analyzing commercial crystallization kit compositions, Shima has revealed key insights into how these powerful auxiliaries can enhance crystal quality and enable structure determination of difficult targets. His work has garnered over 15 citations, with his most-cited 2021 paper serving as a critical reference for researchers employing lanthanide-assisted biocrystallography. Shima’s research bridges fundamental coordination chemistry and practical structural biology, providing a methodological framework that helps crystallographers optimize conditions for high-resolution data collection. His findings are particularly valuable for students and researchers working on membrane proteins or complexes that are notoriously resistant to crystallization. Through his systematic approach, Shima continues to advance the toolkit of macromolecular crystallography, making previously intractable structures accessible to the scientific community.
Research Focus
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Top Papers
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