Susan P. Perrine
Papers
1
Total Citations
27
H-Index
1
About
Dr. Susan P. Perrine is a pioneering hematologist whose research has fundamentally advanced the treatment of beta-hemoglobinopathies, including sickle cell disease and beta-thalassemia. Her work centers on the therapeutic reactivation of fetal hemoglobin (HbF), a natural strategy to ameliorate the severe clinical manifestations of these inherited blood disorders. A landmark contribution is her 2015 study on novel inducers of fetal globin, identified through high-throughput screening. This work demonstrated that safe, orally-bioavailable agents could effectively stimulate γ-globin expression in vivo, showing activity in anemic baboons and transgenic mice. With 27 citations, this paper represents a critical translational step, moving promising compounds from the lab bench toward clinical application. Dr. Perrine’s sustained impact is evident in her development of therapeutic candidates like arginine butyrate and HbF-inducing short-chain fatty acid derivatives, which have progressed into clinical trials. Her research has provided a foundation for safer, more accessible treatments for millions of patients worldwide, marking her as a key figure in the quest to transform hemoglobinopathy care from management to targeted molecular therapy.
Research Focus
Key Achievements
Top Papers
- 1