Stuart F.J. Le Grice
Frederick National Laboratory for Cancer Research, National Cancer Institute
Papers
2
Total Citations
131
H-Index
2
About
Stuart F.J. Le Grice is a distinguished virologist and biochemist whose career has been defined by pioneering research into the molecular mechanisms of retroviral replication, with a particular focus on Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV). His most celebrated contributions center on the enzyme reverse transcriptase and its associated ribonuclease H (RNase H) activity — a critical yet historically underexploited target for antiviral drug development. In 2003, Le Grice and colleagues developed a fluorescence-based high-throughput screening assay for HIV-1 RNase H inhibitors, a methodological breakthrough that garnered 128 citations and opened new avenues for antiretroviral therapeutic discovery. His more recent work has expanded into RNA Packaging Signal (PS)-mediated genome encapsidation, investigating how ssRNA viruses — including HBV — exploit specific RNA structural motifs to ensure faithful and efficient genome packaging during nucleocapsid assembly. This research holds significant promise for the design of novel antivirals targeting viral assembly. Spanning two decades of impactful science, Le Grice's work has meaningfully advanced our understanding of viral replication strategies and the development of targeted molecular therapeutics against devastating infectious diseases.
Research Focus
Key Achievements
Top Papers
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