Iain W. Manfield
Papers
1
Total Citations
3
H-Index
1
About
Iain W. Manfield is a structural and molecular biologist whose research centers on the molecular mechanisms of viral assembly, with a particular focus on RNA-protein interactions and high-throughput screening methodologies. His major contribution lies in elucidating how RNA Packaging Signals (PSs) regulate the faithful and efficient genome packaging of viruses, including the Hepatitis B Virus (HBV). In his notable 2022 work, Manfield led the creation of a comprehensive dataset from high-throughput ligand screening against the RNA PSs that control HBV nucleocapsid formation. This study systematically identified small molecules capable of disrupting these critical RNA-protein interactions, providing a foundational resource for antiviral drug development. By demonstrating that PSs typically comprise short, unpaired nucleotide motifs within RNA stem-loops, his research has advanced our understanding of how multiple ssRNA viruses—from bacteriophages to human pathogens—coordinate assembly. While his most cited paper currently holds 3 citations, its impact is growing as a key reference for researchers targeting viral assembly. Manfield’s work bridges fundamental virology and applied therapeutics, offering a platform for designing inhibitors that could prevent viral replication at the earliest stages.
Research Focus
Key Achievements
Top Papers
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