Steven V. Kheyfets

Indiana University – Purdue University Indianapolis, Indiana University Indianapolis, Indiana University School of Medicine

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About

Steven V. Kheyfets is a urologic surgeon and researcher whose work centers on advancing minimally invasive surgical techniques, particularly in the realm of robotic-assisted partial nephrectomy for renal tumors and angiomyolipomas. His major contributions include pioneering the use of folate-targeted intraoperative fluorescence imaging with OTL38, a novel approach that enhances a surgeon’s ability to visualize tumor margins in real time during robot-assisted laparoscopic procedures. This innovation directly addresses a critical challenge in nephron-sparing surgery—ensuring complete tumor resection while preserving healthy kidney tissue. Kheyfets’ foundational study on this technique, with 43 citations, reported the first three cases and demonstrated its potential to improve oncologic outcomes. He has also evaluated the safety and early effectiveness of robotic partial nephrectomy for large angiomyolipomas across multiple academic centers, contributing to the evidence base for expanding surgical indications. Additionally, his work on training protocols for robotic urologic surgery helps standardize education for future surgeons. With a growing citation impact, Kheyfets is shaping both the technical and educational frontiers of urologic oncology.