Papers
7
Total Citations
515
H-Index
7
About
Stephen Pleasance is a pioneering analytical chemist whose career has spanned decades of innovation in bioanalytical methodology, with particular expertise in liquid chromatography tandem mass spectrometry (LC/MS/MS) and high-throughput sample preparation. Working prominently within pharmaceutical research, he made transformative contributions to drug metabolism and pharmacokinetic studies during the late 1990s and early 2000s, a period of rapid evolution in bioanalysis. His landmark 1999 paper describing the 'GW cocktail' method for simultaneously determining multiple cytochrome P450 probe substrates has garnered 119 citations, reflecting its lasting utility in clinical drug interaction studies. Equally influential was his 1996 work introducing automated 96-well solid phase extraction coupled to tandem mass spectrometry (116 citations), which helped revolutionize high-throughput bioanalysis across the pharmaceutical industry. His contributions extended to chiral separations, glucocorticoid analysis, and protein precipitation techniques, demonstrating remarkable versatility. Notably, Pleasance demonstrated an enduring commitment to scientific innovation by contributing to COVID-19 diagnostics in 2023, developing extraction-free high-throughput SARS-CoV-2 detection methods. His body of work reflects a consistent dedication to pushing the boundaries of analytical efficiency and clinical applicability.
Research Focus
Key Achievements
Top Papers
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- 4Automated protein precipitation by filtration in the 96-well format82 citations · 1999
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