John P. Allanson
Papers
1
Total Citations
116
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About
John P. Allanson is a pioneering figure in bioanalytical chemistry, whose work has fundamentally transformed high-throughput mass spectrometry for pharmaceutical development. His key research areas include automated solid-phase extraction, liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the optimization of sample preparation workflows for drug metabolism and pharmacokinetics. Allanson’s most impactful contribution is his seminal 1996 paper on the use of automated solid-phase extraction in the 96-well format for high-throughput bioanalysis, which has garnered over 116 citations. This work introduced a robust method for determining the 5-HT receptor agonist 311C90 and its desmethyl metabolite in human plasma, leveraging the MicroLuteTM system and robotic automation to dramatically increase sample throughput and reproducibility. By demonstrating the feasibility of integrating 96-well plate technology with LC-MS/MS, Allanson enabled faster, more reliable quantification of drugs and metabolites in complex biological matrices—a breakthrough that accelerated preclinical and clinical studies. His innovations have been widely adopted in the pharmaceutical industry, setting new standards for efficiency and accuracy in bioanalysis. Allanson’s legacy lies in bridging automation and mass spectrometry, empowering researchers to handle larger sample volumes with precision, and his work remains a cornerstone for modern high-throughput drug development.
Research Focus
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