Stephen F. Traynelis
Papers
2
Total Citations
20
H-Index
2
About
Stephen F. Traynelis is a leading neuroscientist whose research centers on the structure, function, and pharmacology of ligand-gated ion channels, particularly N-methyl-D-aspartate (NMDA) receptors. His work bridges fundamental molecular neuroscience and translational therapeutic applications. A major contribution is his pioneering use of automated intracellular electrophysiology for high-throughput screening of ligand-gated ionotropic receptors, a technique that accelerates drug discovery for neurological disorders. His impact is further demonstrated by a landmark double-blind, placebo-controlled pilot study investigating D-cycloserine, a partial NMDA receptor agonist, as a treatment for motor recovery in chronic stroke patients. This study, which has garnered significant attention, directly addresses the critical unmet need for therapies that enhance synaptic plasticity and functional recovery after stroke, a leading cause of disability. By exploring how D-cycloserine can promote NMDA receptor function to improve rehabilitation outcomes, Traynelis has advanced the clinical potential of targeting glutamatergic signaling. His work exemplifies a powerful trajectory from mechanistic ion channel biology to innovative, patient-focused clinical trials.
Research Focus
Key Achievements
Top Papers
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