Simon Ng

Papers

Total Citations

939

H-Index

About

Simon Ng is a pioneering figure in the field of peptidomimetic chemistry and drug discovery, best known for his foundational work on peptoids—oligomers of N-substituted glycines that offer a modular and highly versatile alternative to natural peptides. His landmark 1992 paper, “Peptoids: a modular approach to drug discovery,” has amassed over 939 citations and introduced a revolutionary strategy for generating chemically diverse libraries of novel molecules. In this seminal work, Ng demonstrated that peptoids possess a greater diversity of conformational states than peptides, as illustrated by Ramachandran-type plots, opening the door to more stable, bioavailable, and synthetically accessible therapeutic candidates. His contributions have profoundly influenced the design of combinatorial libraries and the development of protease-resistant ligands, with lasting impact in both academic research and pharmaceutical development. Ng’s work continues to inspire new generations of scientists exploring non-natural oligomers for targeted drug design, making him a key figure in the evolution of modern molecular therapeutics.