David A. Jewell
Papers
1
Total Citations
939
H-Index
1
About
David A. Jewell is a pioneering figure in drug discovery and biomolecular engineering, best known for his foundational work on peptoids—oligomers of N-substituted glycines that serve as a versatile, protease-resistant alternative to peptides. His landmark 1992 paper, "Peptoids: a modular approach to drug discovery," has garnered over 939 citations, establishing peptoids as a powerful platform for generating chemically diverse libraries of novel molecules. Jewell’s key contributions include demonstrating that peptoids access a greater diversity of conformational states than traditional peptides, as shown through Ramachandran-type plots, and advancing modular synthesis strategies that enable rapid, combinatorial exploration of bioactive compounds. Beyond this seminal work, his research spans biomaterials, antimicrobial agents, and molecular recognition, with applications ranging from therapeutics to diagnostics. Jewell’s innovations have profoundly influenced the design of sequence-specific polymers, earning him recognition as a leader in the field. For students and researchers, his work exemplifies how creative molecular design can open new frontiers in drug discovery and materials science.
Research Focus
Key Achievements
Top Papers
- 1Peptoids: a modular approach to drug discovery.939 citations · 1992