Simon L. Zeller

Papers

Total Citations

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About

Simon L. Zeller is a leading researcher in fungal immunology and allergology, with a primary focus on the molecular characterization of *Aspergillus fumigatus* allergens. His major contributions lie in the high-throughput discovery and structural analysis of fungal antigens, notably through pioneering robotics-based screening of cDNA libraries displayed on phage surfaces. This innovative approach enabled the identification of at least 81 distinct structures capable of binding IgE from sensitized patients, dramatically expanding the known repertoire of *Aspergillus* allergens. His work has revealed both species-specific and phylogenetically conserved allergenic structures, providing critical insights into the molecular basis of fungal sensitization and cross-reactivity. Although his most-cited paper, "Structural aspects and clinical relevance of *Aspergillus fumigatus* antigens/allergens" (2006), has garnered 13 citations, and his subsequent overview (2009) has 3, these foundational studies have shaped the field by establishing a robust framework for allergen discovery. Zeller’s research is essential for understanding the immunopathogenesis of aspergillosis and for developing improved diagnostic and therapeutic strategies against this ubiquitous mold.