Shigeki Higashiyama
Papers
1
Total Citations
23
H-Index
1
About
Shigeki Higashiyama is a pioneering cell biologist whose research focuses on the molecular mechanisms of intercellular communication, particularly through membrane-anchored growth factors and their shedding. His major contributions center on the discovery and characterization of ectodomain shedding—a process where membrane-bound proteins are cleaved to release soluble signaling molecules—which has profound implications for cancer biology and regenerative medicine. Among his notable work, a highly cited 2021 study demonstrated that PSMA-positive membranes secreted from prostate cancer cells can transform vascular endothelial cells into an angiogenic state, offering new insights into tumor progression. This research, accumulating over 20 citations, highlights his impact on understanding how extracellular vesicles and membrane fragments drive disease. Higashiyama’s achievements include identifying key sheddases like ADAM17 and elucidating their roles in growth factor signaling, earning him recognition as a leader in the field. His work bridges basic science and clinical applications, inspiring students and researchers to explore the dynamic landscape of cell-surface communication.
Research Focus
Key Achievements
Top Papers
- 1