Shelley Darnbrough
Papers
1
Total Citations
16
H-Index
1
About
Shelley Darnbrough is a synthetic organic chemist whose work has advanced the field of solid-phase peptide and olefin synthesis. Her key research areas include the development of novel methodologies for carbon-carbon bond formation and the application of solid-phase techniques to streamline complex organic reactions. Darnbrough’s most notable contribution is her pioneering study on the solid-phase Horner–Emmons synthesis of olefins, where she systematically explored the use of three distinct resin-bound phosphonates with sixteen diverse aldehydes. This work, which has garnered 16 citations, demonstrated the versatility and attractiveness of the Horner–Emmons condensation for generating olefins in a solid-phase format, offering a powerful tool for combinatorial chemistry and drug discovery. By enabling efficient, resin-based olefination, Darnbrough’s research has provided a practical pathway for constructing carbon-carbon bonds in a controlled, high-throughput manner. Her achievements highlight her expertise in synthetic methodology and her commitment to advancing practical, scalable techniques for organic synthesis, making her work a valuable reference for researchers in solid-phase chemistry and beyond.
Research Focus
Key Achievements
Top Papers
- 1Solid-Phase Horner−Emmons Synthesis of Olefins16 citations · 1999