Johannes G. de Vries
DSM (Netherlands), University of Groningen, Leibniz Institute for Catalysis
Papers
3
Total Citations
258
H-Index
3
About
Johannes G. de Vries is a distinguished chemist whose career has been defined by pioneering contributions to asymmetric catalysis and the development of efficient methodologies for fine chemical synthesis. His research sits at the intersection of organometallic chemistry, ligand design, and high-throughput experimentation, with a particular focus on making enantioselective catalysis more accessible and practical for industrial applications. De Vries has made landmark advances in the use of monodentate phosphoramidite ligands, demonstrating their remarkable effectiveness in rhodium-catalyzed asymmetric transformations. His 2004 work on the highly enantioselective conjugate addition of potassium organotrifluoroborates to enones — garnering 120 citations — showcased how systematic high-throughput screening could unlock superior catalytic performance. Building on this, his influential 2006 paper (135 citations) outlined a combinatorial approach to asymmetric hydrogenation, introducing phosphoramidite libraries and artificial enzyme strategies to dramatically accelerate catalyst discovery, a contribution that has shaped modern approaches to ligand optimization. His continued work on rhodium-catalyzed hydrogenations using monodentate ligands reflects a sustained commitment to refining these methodologies. De Vries's research has profoundly influenced how the chemical community approaches enantioselective synthesis, bridging academic innovation with real-world pharmaceutical and fine chemical manufacturing.
Research Focus
Key Achievements
Top Papers
- 1
- 2
- 3Rhodium-Catalysed Hydrogenations Using Monodentate Ligands3 citations · 2017