Roxane Legaie
Papers
1
Total Citations
64
H-Index
1
About
Roxane Legaie is a leading researcher in bacterial systems biology, with a focus on the metabolic and regulatory networks of *Streptomyces*—soil-dwelling bacteria renowned for their production of clinically vital secondary metabolites, including antibiotics. Her major contributions center on elucidating how these organisms adapt their metabolism and gene expression in response to nutrient availability and environmental stress. In her highly cited 2011 study (64 citations), Legaie employed a proteomic approach to map the dynamic metabolic switches in *Streptomyces coelicolor* wild type and a *phoP* mutant during batch culture. This work revealed that global mRNA expression undergoes a series of coordinated metabolic and regulatory shifts over the bacterial lifespan, providing a foundational framework for understanding how *Streptomyces* transitions from primary to secondary metabolism. By integrating proteomics with transcriptomics, Legaie’s research has profound implications for optimizing antibiotic production and deciphering bacterial adaptation to oligotrophic environments. Her achievements underscore her role in advancing the systems-level understanding of microbial physiology, making her work essential reading for researchers in synthetic biology, metabolic engineering, and natural product discovery.
Research Focus
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Top Papers
- 1