David A. Hodgson
Papers
1
Total Citations
64
H-Index
1
About
David A. Hodgson is a leading microbiologist whose research centers on the regulatory and metabolic networks that govern bacterial adaptation, particularly in *Streptomyces* species—soil-dwelling bacteria renowned for their production of clinically vital secondary metabolites. His major contributions include elucidating how global regulatory systems, such as the PhoP response regulator, orchestrate metabolic switches during nutrient-limited growth. In a landmark 2011 study (64 citations), Hodgson and his team used proteomic profiling of *Streptomyces coelicolor* wild-type and *phoP* mutant strains to reveal how the bacterium dynamically reconfigures its metabolism in batch culture, transitioning from primary to secondary metabolism. This work provided a systems-level view of the molecular adaptations that underpin antibiotic production, offering insights for engineering improved yields. His research has been instrumental in connecting transcriptional regulation to metabolic flux, with his findings cited widely in both fundamental microbiology and applied biotechnology. Hodgson’s work remains a cornerstone for understanding how oligotrophic bacteria thrive and produce bioactive compounds, making him a key figure in the field of bacterial physiology and natural product discovery.
Research Focus
Key Achievements
Top Papers
- 1