Rosamond G. Jackson
Papers
1
Total Citations
31
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1
About
Rosamond G. Jackson is a structural biologist whose work illuminates the molecular mechanisms of bacterial bioremediation. Her research centers on the structural and functional characterization of unusual cytochrome P450 enzymes, particularly those involved in the degradation of recalcitrant environmental pollutants. Jackson’s major contribution is the elucidation of the 1.5-Å crystal structure of the XplA-heme domain, a unique cytochrome P450 that is naturally fused to its flavodoxin redox partner. This groundbreaking work, published in 2009 and cited over 30 times, revealed the atomic details of how this enzyme catalyzes the reductive biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a toxic nitramine explosive and persistent environmental contaminant. By solving this high-resolution structure, Jackson provided the first detailed view of a P450 system capable of breaking down RDX, offering critical insights for engineering bioremediation strategies. Her findings have significant implications for cleaning up military training sites and munitions-contaminated environments, showcasing how structural biology can directly inform environmental biotechnology.
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