Girish Tampi
Papers
1
Total Citations
31
H-Index
1
About
Girish Tampi is a structural biologist whose research focuses on the molecular mechanisms of enzymes with significant biotechnological and environmental applications. His most notable contribution is the elucidation of the 1.5-Å crystal structure of the XplA-heme domain, a unique cytochrome P450 fused to a flavodoxin redox partner. This groundbreaking work, published in 2009 and cited over 30 times, revealed the structural basis for how XplA, in concert with its partner XplB, catalyzes the reductive breakdown of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a toxic nitramine explosive and persistent environmental pollutant. By providing the first high-resolution view of this unusual P450 system, Tampi’s research has paved the way for engineering bioremediation strategies to clean up military training sites and contaminated soils. His work stands as a key achievement in the field of environmental enzymology, demonstrating how atomic-level structural insights can inform the development of sustainable solutions for degrading recalcitrant industrial compounds.
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