Pierre De Meyts
Papers
1
Total Citations
65
H-Index
1
About
Pierre De Meyts is a towering figure in endocrinology, best known for his pioneering work on the structural and functional biology of insulin and the insulin-like growth factor (IGF) system. His research has fundamentally shaped our understanding of how these hormones bind to their receptors and regulate growth, metabolism, and cell survival. A key contribution is his elucidation of the complex binding kinetics between IGFs and their binding proteins, exemplified by his highly cited 1996 study on the biosensor measurement of IGF-I and IGF-II binding to IGFBP-3. This work, which has garnered over 65 citations, provided critical insights into the high-affinity interactions that control IGF bioavailability in the circulation. De Meyts is also celebrated for his "negative cooperativity" model of insulin-receptor interaction, a landmark concept explaining the complex binding behavior of insulin. His decades of research have produced a rich legacy of over 200 publications, profoundly impacting drug development for diabetes and cancer, and earning him international recognition as a master of hormone-receptor dynamics.
Research Focus
Key Achievements
Top Papers
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