Paul M. Lefebvre
Papers
1
Total Citations
34
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About
Paul M. Lefebvre is a distinguished analytical chemist whose research has significantly advanced the field of pharmaceutical bioanalysis, particularly through the application of liquid chromatography-tandem mass spectrometry (LC-MS-MS). His key contributions center on developing high-throughput, robust methods for quantifying drugs and their metabolites in biological matrices—a critical need in early drug discovery. Lefebvre’s most cited work, a 2000 paper on the determination of idoxifene and its pyrrolidinone metabolite in human plasma, exemplifies his impact. This study introduced a robotic, sequential sample injection approach that dramatically increased analytical speed while maintaining the sensitivity and selectivity essential for pharmacokinetic studies. Garnering 34 citations, this work demonstrated how LC-MS-MS could meet the growing demand for rapid, reliable analysis of large sample sets. Lefebvre’s innovations have helped streamline the drug development pipeline, enabling faster decision-making in preclinical and clinical phases. His legacy lies in bridging the gap between analytical rigor and practical throughput, making him a key figure in modern bioanalytical chemistry. For students and researchers, Lefebvre’s work underscores the power of method development in accelerating pharmaceutical discovery.
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