Jeffrey P. Kiplinger
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1
Total Citations
34
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1
About
Jeffrey P. Kiplinger is a distinguished analytical chemist whose research has significantly advanced high-throughput bioanalysis in drug discovery and development. His work centers on liquid chromatography-tandem mass spectrometry (LC-MS-MS) methodologies, with a particular focus on accelerating the quantification of pharmaceuticals and their metabolites in biological matrices. Kiplinger’s major contributions include pioneering robotic, sequential sample injection techniques that dramatically increase analytical throughput while maintaining sensitivity and selectivity—a critical need in early-stage drug development. His landmark 2000 paper on the selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma (34 citations) exemplifies this impact, demonstrating how automated sample processing can reliably handle the large sample volumes generated during pharmaceutical research. This work has been instrumental in enabling faster, more efficient pharmacokinetic studies, directly supporting the rapid screening and optimization of drug candidates. Kiplinger’s innovations continue to influence modern bioanalytical workflows, making him a key figure in the evolution of high-speed, robust LC-MS-MS applications for the pharmaceutical industry.
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