Jack D. Henion
Papers
6
Total Citations
311
H-Index
5
About
Jack D. Henion is a pioneering analytical chemist whose career has been defined by transformative advances in mass spectrometry-based bioanalytical methods, particularly at the intersection of liquid chromatography, capillary electrophoresis, and tandem mass spectrometry. His groundbreaking work on coupling capillary electrophoresis with atmospheric pressure ionization mass spectrometry, published in 1991 and now carrying 95 citations, helped establish CE-MS as a powerful platform for peptide and protein characterization. Henion has been equally influential in high-throughput bioanalytical workflows, developing robust 96-well solid-phase extraction technologies for the quantitative determination of estrogen sulfates in human urine — a study garnering 118 citations that set a benchmark for clinical and pharmaceutical analyses. His contributions extend to dried blood spot analysis, automated SPE card devices, and liquid extraction surface analysis mass spectrometry (LESA-MS), reflecting a sustained commitment to miniaturized, automated, and clinically relevant sample preparation strategies. His selected reaction monitoring LC-MS/MS methods for drug metabolite quantitation have further accelerated pharmaceutical drug discovery pipelines. Across decades of innovation, Henion's work has profoundly shaped modern bioanalytical chemistry, making sensitive, selective, and high-throughput mass spectrometric analysis accessible for both research and clinical applications.
Research Focus
Key Achievements
Top Papers
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