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About

Paola Arlotta is a pioneering developmental neurobiologist whose work has fundamentally reshaped our understanding of how the human cerebral cortex is built. Her research focuses on the molecular mechanisms that govern neural stem cell fate, neuronal diversity, and the assembly of complex neural circuits. Arlotta is best known for her groundbreaking use of single-cell genomics to map the developing human brain, revealing the extraordinary diversity of cell types and their lineage relationships. Her lab’s contributions have provided a critical blueprint for understanding neurodevelopmental disorders such as autism and schizophrenia. With over 6,000 citations, her most influential work includes the first comprehensive single-cell atlas of the developing human cortex, a landmark achievement that has become a foundational resource for the field. A Harvard University professor and an Institute Member of the Broad Institute, Arlotta is also a passionate advocate for organoid research, using these “mini-brains” to model disease and test therapeutic strategies. Her visionary approach to engineering multicellular living systems continues to inspire a new generation of neuroscientists.