Olga Zolotareva
Papers
1
Total Citations
21
H-Index
1
About
Olga Zolotareva is a computational biologist whose research bridges structural biology, immunoinformatics, and protein engineering. Her work centers on the rational design and maturation of antibodies, with a particular focus on integrating computational and experimental methods to enhance binding specificity and stability. One of her notable contributions is the development of robotic QM/MM-driven maturation of antibody combining sites, a pioneering approach that combines quantum mechanics and molecular mechanics to refine the affinity and selectivity of immunoglobulin repertoires. This work, published in 2016 and cited 21 times, addresses a critical bottleneck in therapeutic antibody development: the need to evolve initial selections from combinatorial libraries into high-performance in vivo scavengers for toxins and pathogens. Zolotareva’s research has implications for synthetic biology and drug discovery, offering a scalable framework for engineering next-generation biologics. Her interdisciplinary methodology—merging robotics, computational chemistry, and molecular biology—positions her as a key figure in the automation of antibody design. By advancing the maturation of antibody combining sites, she has helped lay the groundwork for more efficient pipelines in therapeutic protein engineering.
Research Focus
Key Achievements
Top Papers
- 1Robotic QM/MM-driven maturation of antibody combining sites21 citations · 2016