Matthias Wilmanns

Papers

Total Citations

H-Index

About

Matthias Wilmanns is a leading structural biologist whose research bridges the molecular mechanisms of protein function with innovative biotechnological applications. His primary focus lies in understanding the structural biology of large macromolecular complexes, particularly those involved in cellular signaling and metabolic regulation. Wilmanns is renowned for his pioneering work on the structural and functional characterization of the 26S proteasome, the cellular machinery responsible for protein degradation, and for elucidating the architecture of key signaling complexes like the Hippo pathway. A hallmark of his career is the integration of cutting-edge structural methods—including X-ray crystallography, cryo-electron microscopy, and hybrid approaches—with functional studies. His notable contributions include the development of robotic QM/MM-driven maturation of antibody combining sites, a method that combines computational and experimental evolution to enhance antibody affinity, as demonstrated in his 2016 work (21 citations). With over 150 publications and an h-index exceeding 60, Wilmanns’ work has profoundly impacted our understanding of protein assembly and degradation, earning him recognition as a senior group leader at the European Molecular Biology Laboratory (EMBL) Hamburg. His research continues to inspire students and researchers exploring the frontiers of structural biology and therapeutic design.