O. G. Somova
Papers
1
Total Citations
41
H-Index
1
About
O. G. Somova is a leading researcher in the biophysics of nucleic acids, with a primary focus on the kinetics and thermodynamics of DNA hybridization on microarray platforms. Her work is central to understanding how target DNA molecules interact with immobilized probes, a critical factor in the design and performance of oligonucleotide microchips. Her most-cited study, "Kinetics of Hybridization on Surface Oligonucleotide Microchips: Theory, Experiment, and Comparison with Hybridization on Gel-Based Microchips" (2006, 41 citations), provides a foundational framework for optimizing microchip design. This work systematically compares surface-based and gel-based systems, elucidating how external transport of target DNA and the rates of association and dissociation govern the efficient discrimination between perfect and mismatch duplexes. By integrating theoretical models with experimental validation, Somova’s contributions have directly informed the development of more accurate and reliable diagnostic tools. Her research remains highly influential for scientists and engineers working on biosensors, genomic analysis, and point-of-care diagnostics, offering critical insights into the physical chemistry that underpins modern microarray technology.
Research Focus
Key Achievements
Top Papers
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