A. Yu. Turygin
Papers
1
Total Citations
41
H-Index
1
About
A. Yu. Turygin is a distinguished researcher whose work lies at the intersection of biophysics, surface chemistry, and microarray technology. Their primary contributions center on the kinetics of DNA hybridization on solid supports, a critical factor in the design and optimization of oligonucleotide microchips. Turygin’s most cited paper (2006, 41 citations) provides a comprehensive theoretical and experimental analysis of hybridization kinetics on surface-based microchips, comparing them with gel-based alternatives. This work elucidates how external transport of target DNA to immobilized probes, along with association and dissociation rates, governs the efficient discrimination between perfect and mismatch duplexes—a cornerstone for accurate genetic diagnostics. By bridging theory and experiment, Turygin has advanced the rational design of microarrays, enhancing their sensitivity and specificity. Their research has profound implications for genomics, personalized medicine, and biosensor development, offering practical guidelines for improving hybridization efficiency. Turygin’s work continues to influence the field, providing a foundational framework for researchers seeking to optimize surface-based nucleic acid assays.
Research Focus
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Top Papers
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