Nicole C. Hauser

Papers

Total Citations

131

H-Index

About

Nicole C. Hauser is a pioneering molecular biologist whose work has fundamentally advanced functional genomics in the model organism *Saccharomyces cerevisiae*. Her landmark 1998 study, "Transcriptional profiling on all open reading frames of *Saccharomyces cerevisiae*," stands as a foundational achievement in the field, earning over 130 citations. In this seminal contribution, Hauser and her team systematically PCR-amplified all 6,116 open reading frames from the yeast genome using an impressive 12,232 custom primers, achieving a remarkable 97% amplification success rate. By arraying these PCR products at extremely high density for hybridization, she created one of the first comprehensive platforms for genome-wide transcriptional profiling. This work enabled researchers to monitor the expression of virtually every yeast gene in a single experiment, revolutionizing the study of cellular responses to environmental changes, genetic perturbations, and drug treatments. Hauser’s technical rigor and large-scale approach helped establish the standards for microarray-based genomics, making her a key figure in the transition from single-gene studies to systems biology. Her contributions continue to empower countless investigations into gene regulation, metabolism, and disease mechanisms in yeast and beyond.