Bernhard Krems
Papers
1
Total Citations
131
H-Index
1
About
Bernhard Krems is a pioneering molecular biologist whose work has fundamentally advanced the functional genomics of *Saccharomyces cerevisiae*. His key research areas include high-throughput transcriptional profiling and genome-wide analysis of gene expression. Krems’s most notable contribution is his landmark 1998 study, which systematically PCR-amplified all 6,116 open reading frames of budding yeast, achieving a remarkable 97% success rate using over 12,000 specific primers. This work enabled the creation of comprehensive DNA microarrays, allowing researchers to probe the entire yeast transcriptome for the first time. With 131 citations, this foundational resource has been instrumental in unraveling gene function, regulatory networks, and cellular responses in yeast—a model organism critical to genetics and biotechnology. Krems’s achievement exemplifies the power of systematic, large-scale approaches in the post-genomic era, providing a template for similar studies in other organisms. His dedication to open-access genomic tools has empowered countless scientists to explore the molecular basis of life, making him a key figure in the transition from single-gene studies to global expression analysis.
Research Focus
Key Achievements
Top Papers
- 1Transcriptional profiling on all open reading frames ofSaccharomyces cerevisiae131 citations · 1998